医学
间充质干细胞
脊髓损伤
移植
髂嵴
干细胞
外科
脊髓
干细胞疗法
病理
生物
精神科
遗传学
作者
Euler Moraes Penha,Paulo Henrique Palis Aguiar,Stella Maria Barrouin‐Melo,Ricardo Santana de Lima,Ana Carolina C. da Silveira,Ana Rosa S. Otelo,Cláudia Maria Bahia Pinheiro,Ricardo Ribeiro-dos-Santos,Milena Botelho Pereira Soares
出处
期刊:International journal of stem cells
[Korean Society for Stem Cell Research]
日期:2012-11-30
卷期号:5 (2): 146-150
被引量:13
标识
DOI:10.15283/ijsc.2012.5.2.146
摘要
Stem cell-based therapy has been investigated in a number of degenerative and traumatic diseases, including spinal cord injury. In the present study, we investigated the use of autologous mesenchymal stem cells in the functional rehabilitation of a domestic cat presenting a compressive L1-L5 fracture. Bone marrow cells collected by puncture of the iliac crest were cultured to obtain mesenchymal stem cells three weeks before surgery. Hemilaminectomy was performed, followed by injection of the mesenchymal stem cells in the injured area. Clinical evaluation of the animal prior to surgery showed absence of pain, muscular tonus, and panniculi reflexes. Seven days after surgery and cell transplantation the examination revealed a progressive recovery of the panniculus reflexes and of the responses to superficial and deep pain stimuli despite the low proprioceptive and hyperreflexic ataxic hind limbs. Physiotherapy protocols were applied for clinical rehabilitation after surgery. The cat's first steps, three-minute weight-bearing, and intestine and urinary bladder partial reestablishment were observed 75 days post-surgery. Our results indicate the therapeutic potential of mesenchymal stem cells in chronic spinal cord injuries.
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