细胞生物学
生物
转录因子
淋巴毒素
Wnt信号通路
间质细胞
胸腺细胞
细胞分化
自身免疫调节因子
FGF8型
祖细胞
细胞命运测定
旁分泌信号
干细胞
成纤维细胞生长因子
免疫学
信号转导
T细胞
癌症研究
遗传学
受体
免疫系统
基因
作者
Lina Sun,Huai‐Rong Luo,Hongran Li,Yong Zhao
出处
期刊:Protein & Cell
[Springer Nature]
日期:2013-04-15
卷期号:4 (5): 342-355
被引量:27
标识
DOI:10.1007/s13238-013-3014-0
摘要
Thymic epithelial cells (TECs) are one of the most important components in thymic microenvironment supporting thymocyte development and maturation. TECs, composed of cortical and medullary TECs, are derived from a common bipotent progenitor, mediating thymocyte positive and negative selections. Multiple levels of signals including intracellular signaling networks and cell-cell interaction are required for TEC development and differentiation. Transcription factors Foxn1 and autoimmune regulator (Aire) are powerful regulators promoting TEC development and differentiation. Crosstalks with thymocytes and other stromal cells for extrinsic signals like RANKL, CD40L, lymphotoxin, fibroblast growth factor (FGF) and Wnt are also definitely required to establish a functional thymic microenvironment. In this review, we will summarize our current understanding about TEC development and differentiation, and its underlying multiple signal pathways.
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