诱导多能干细胞
再生医学
干细胞
细胞生物学
生物
重编程
胚胎干细胞
计算生物学
细胞疗法
细胞分化
胚状体
细胞
电池类型
出处
期刊:Current Stem Cell Research & Therapy
日期:2010-08-31
卷期号:5 (3): 207-214
被引量:16
标识
DOI:10.2174/157488810791824548
摘要
The pressing demand to elucidate the biology of human embryonic stem (ES) cells and to realize their therapeutic potential has greatly promoted the progresses in the optimization of the culture systems used for this highly promising cell type. These progresses include the characterization of exogenous regulators of pluripotency and differentiation, the development of animal-free, defined, and scalable culture systems, and some pioneering efforts to establish good manufactory practice facilities to derive and expand clinical-grade human ES cells and their derivatives. All of these advancements appear to be also applicable to the derivation and culture of human induced pluripotent stem cells, an ES cell-like cell type derived from somatic cells via reprogramming. This review attempts to summarize these progresses and discuss some of the remaining challenges.
科研通智能强力驱动
Strongly Powered by AbleSci AI