肝素结合EGF样生长因子
劈理(地质)
细胞内
细胞生物学
表皮生长因子
生长因子
化学
细胞信号
信号转导
生物化学
生物
受体
古生物学
断裂(地质)
作者
Daisuke Nanba,Shigeki Higashiyama
标识
DOI:10.1016/j.cytogfr.2003.10.002
摘要
Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent studies indicate that the processing of proHB-EGF is strictly regulated and involved in a variety of biological processes and that not only HB-EGF but also HB-EGF-C functions as a signaling molecule. ProHB-EGF generates dual intracellular signaling molecules by its proteolytic cleavage.
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