A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate

We have developed a facile synthesis of sialylated oligolactosamine glycans, including Neu5Ac-α-2,3LacNAc-β-1,3LacNAc (3′SLN-LN) and Neu5Ac-α-2,3LacNAc-β-1,3LacNAc-β-1,3LacNAc (3′SLN-LN-LN), also providing a useful method for the preparation of 2-amino sugar building blocks.