Pedigree and genetic analysis of a novel mutation carrier patient suffering from hereditary nonpolyposis colorectal cancer

hMSH2 gene might be responsible for the development of colon cancers.In family members where the exon 7 mutation is not coupled with this missense mutation, colon cancer appears after the age of 40.The association of these two mutations seems to decrease the age of manifestation of the disease into the early thirties.