特立帕肽
医学
骨质疏松症
腰椎
外科
泌尿科
骨矿物
内科学
作者
Gen Inoue,Masaki Ueno,Takahiro Nakazawa,Takayuki Imura,Wataru Saito,Katsuhisa Uchida,Seiji Ohtori,Tomoaki Toyone,Naonobu Takahira,Masashi Takaso
出处
期刊:Journal of neurosurgery
[Journal of Neurosurgery Publishing Group]
日期:2014-09-01
卷期号:21 (3): 425-431
被引量:68
标识
DOI:10.3171/2014.5.spine13656
摘要
Object The object of this study was to examine the efficacy of preoperative teriparatide treatment for increasing the insertional torque of pedicle screws during fusion surgery in postmenopausal women with osteoporosis. Methods Fusion surgery for the thoracic and/or lumbar spine was performed in 29 postmenopausal women with osteoporosis aged 65–82 years (mean 72.2 years). The patients were divided into 2 groups based on whether they were treated with teriparatide (n = 13) or not (n = 16) before the surgery. In the teriparatide-treated group, patients received preoperative teriparatide therapy as either a daily (20 μg/day, n = 7) or a weekly (56.5 μg/week, n = 6) injection for a mean of 61.4 days and a minimum of 31 days. During surgery, the insertional torque was measured in 212 screws inserted from T-7 to L-5 and compared between the 2 groups. The correlation between the insertional torque and the duration of preoperative teriparatide treatment was also investigated. Results The mean insertional torque value in the teriparatide group was 1.28 ± 0.42 Nm, which was significantly higher than in the control group (1.08 ± 0.52 Nm, p < 0.01). There was no significant difference between the daily and the weekly teriparatide groups with respect to mean insertional torque value (1.34 ± 0.50 Nm and 1.18 ± 0.43 Nm, respectively, p = 0.07). There was negligible correlation between insertional torque and duration of preoperative teriparatide treatment (r 2 = 0.05, p < 0.01). Conclusions Teriparatide injections beginning at least 1 month prior to surgery were effective in increasing the insertional torque of pedicle screws during surgery in patients with postmenopausal osteoporosis. Preoperative teriparatide treatment might be an option for maximizing the purchase of the pedicle screws to the bone at the time of fusion surgery.
科研通智能强力驱动
Strongly Powered by AbleSci AI