Tofacitinib Citrate for the Treatment of Vitiligo

Importance

Vitiligo is a common condition that is often emotionally devastating for patients. At present, no reliably effective treatments are available.

Observations

Recent advances in the understanding of the pathogenesis of vitiligo suggest that Janus kinase inhibitors may be a therapeutic option. We report a case of generalized vitiligo for which treatment with tofacitinib citrate, an oral Janus kinase 1/3 inhibitor, resulted in significant repigmentation.

Conclusions and Relevance

The results suggest that tofacitinib and other Janus kinase inhibitors may be effective in the treatment of vitiligo. Additional studies will be needed to confirm their efficacy and to explore their safety.