Visible-Light-Induced Lactone-Fused Indoline Construction via Radical Dearomatization of Indoles with Alcohols

We report a visible-light-induced strategy for synthesizing lactone-fused indolines via the radical dearomatization of indoles with simple alcohols. This method combines hydrogen atom transfer (HAT) catalysis and Lewis acid activation operating under ambient conditions. The protocol exhibits a broad substrate scope and excellent diastereoselectivity, leveraging readily available alcohols as alkyl radical precursors. This sustainable approach provides efficient access to complex heterocyclic scaffolds commonly found in bioactive natural products.