Size-dependent lymphatic delivery of Gd-based MRI contrast agents: insights from in vivo studies

WI) and validated by chlorophosphonazo III (CPN III) staining. Furthermore, subcutaneous tumor models were employed to probe the interplay between lymphatic transport and tumor microenvironments. This work moves the field forward by providing a framework to guide the design of lymphatic delivery drugs, turning material-specific observations into universal, size-informed design principles applicable across diverse platforms.