Bridging the Generalist–Subspecialist Gap with GPT-5-Thinking: Dual-Center Evaluation in Orbital and Head-and-Neck Tumor MRI Reports

< .001) in patients with head-and-neck tumors. Conclusion Using MRI reports of patients with orbital or head-and-neck tumors, Generative Pretrained Transformer (GPT)-5-Thinking showed diagnostic accuracy similar to that of subspecialists; GPT-5-Thinking assistance was also associated with higher generalist diagnostic accuracy. © RSNA, 2026