医学
鼻咽癌
长春新碱
放射治疗
环磷酰胺
化疗
阶段(地层学)
阿霉素
内科学
肿瘤科
佐剂
外科
生物
古生物学
作者
M Gasparini,Fabrizio Lombardi,L Rottoli,Emanuela Ballerini,Francesco Morandi
标识
DOI:10.1200/jco.1988.6.3.491
摘要
Twelve children younger than 16 years affected by undifferentiated nasopharyngeal carcinoma (NPC) with advanced primary tumor (T3, T4) were treated with chemotherapy consisting of Adriamycin (ADM [doxorubicin; Adria Laboratories, Columbus, OH]), vincristine (VCR), and cyclophosphamide (CYC), and radiotherapy. Preradiation chemotherapy produced partial responses in eight of ten evaluable patients. Eleven of 12 patients achieved a complete response following radiotherapy. The actuarial 3-year continuous relapse-free survival (CRFS) was 75%. This represents a significant improvement when compared with the 8% rate obtained in a previous series of patients treated with radiotherapy either with or without adjuvant CYC.
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