金黄色葡萄球菌
微生物学
植物乳杆菌
唾液乳杆菌
碳酸钙-2
乳酸菌
胃肠道
体外
生物
病菌
细菌
化学
乳酸
生物化学
遗传学
作者
Dayong Ren,Chang Li,Yanqing Qin,Ronglan Yin,Xiao Li,Mingyao Tian,Shouwen Du,Huanhuan Guo,Cunxia Liu,Na Zhu,Dong Sun,Yang Li,Ningyi Jin
出处
期刊:Anaerobe
[Elsevier]
日期:2012-10-01
卷期号:18 (5): 508-515
被引量:55
标识
DOI:10.1016/j.anaerobe.2012.08.001
摘要
Staphylococcus aureus is an opportunistic pathogen that can colonize human and animal intestinal tracts, causing certain gastrointestinal diseases. The adherence of enteric pathogens to host intestinal epithelial cells is important for their pathogenesis. In the present study, Lactobacillus salivarius and Lactobacillus plantarum were investigated in vitro to examine their ability to competitively exclude S. aureus. Various factors involved in attachment, including bacterial status and cell concentration, growth phase, competition patterns, and surface-layer protein extracts, were also investigated. Live lactobacilli in the mid-log growth phase exhibited maximum inhibitory activity when lactobacilli were pre- or co-incubated with S. aureus. However, the inhibitory activity was significantly reduced when the lactobacilli were inactivated by heating or treated with LiCl. Furthermore, both lactobacilli possessed certain cell surface properties, such as hydrophobicity, autoaggregation, and coaggregation ability. L. salivarius and L. plantarum strongly inhibited S. aureus adherence to Caco-2 cells and their inhibition activity was significantly influenced by several factors that affect adhesion inhibition.
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