Objective: To explore the clinical significance of Ang-2 in the diagnosis of malignant tumor of gastrointestinal tract.Methods:The serum contents of Ang-2 in 56 cases of malignant tumors in gastrointestinal tract and 12 cases of healthy subjects were measured by ELISA.The results were analyzed with SPSS11.0.Results:The serum contents of Ang-2 in patients with malignant tumor in gastrointestinal tract were significantly higher than those in healthy group(P0.05).There was no difference in the content of serum Ang-2 between gastric cancer and intestinal malignant tumor(P0.05).Conclusion:It is valuable to determine the serum content of Ang-2 for diagnosis of malignant tumor in gastrointestinal tract.