化学
卤素
芳基
水溶液
碘化氢
药物化学
羰基
有机化学
碘化物
氢
羧酸
产量(工程)
烷基
冶金
材料科学
作者
Shoji Matsumoto,Hayato Marumoto,Motohiro Akazome,Yasuhiko Otani,Tatsuo Kaiho
标识
DOI:10.1246/bcsj.20200341
摘要
The selective reduction of α,β-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of an aryl group at an α or β position efficiently facilitated the reduction with good yield. The reaction was applicable to compounds bearing carboxylic acids and halogen atoms. Through the investigation of the reaction mechanism, it was found that Michael-type addition of iodide occurred to produce β-iodo compounds followed by the reduction of C-I bond via anionic and radical paths. The selective reduction of α,β-unsaturated carbonyl compounds was achieved to produce saturated carbonyl compounds with aqueous HI solution. The introduction of aryl group at α or β position was efficient to proceed the reduction with a good yield. The reaction was able to apply the compounds bearing carboxylic acid and halogen atom.
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