In the article number 1901429, Yan Wang, Jianliang Cao, Tianyi Ma and co-workers review the up-to-date studies of host-guest recognition on 2D graphitic carbon nitride (g-C3N4) for ion, gas and humidity sensors, as well as for biosensors. The future perspective and remaining challenges in this field are given to provide new thoughts on the graphitic carbon nitride based sensing platform.