mTORC1型
雷氏菌
亮氨酸
氨基酸
摄入
PI3K/AKT/mTOR通路
合成代谢
P70-S6激酶1
内分泌学
内科学
骨骼肌
雷帕霉素的作用靶点
化学
生物化学
生物
细胞生物学
信号转导
医学
作者
Sarkis J. Hannaian,Nathan Hodson,Sidney Abou Sawan,Michael Mazzulla,Hiroyuki Kato,Keiko Matsunaga,Marcus Waskiw-Ford,Justin Duncan,Dinesh Kumbhare,Daniel R. Moore
标识
DOI:10.1152/japplphysiol.00241.2020
摘要
This is the first study to investigate whether postexercise leucine-enriched amino acid (LEAA) ingestion elevates mTORC1 translocation and protein-protein interactions in human skeletal muscle. Here, we observed that although LEAA ingestion did not further elevate postexercise MyoPS or mTORC1 signaling compared with placebo, mTORC1 peripheral location and interaction with Rheb were maintained. This may serve to “prime” mTORC1 for subsequent anabolic stimuli.
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