Facile Electrochemically Reduced Graphene Oxide‐Multi‐walled Carbon Nanotube Nanocomposite as Sensitive Probe for in‐vitro Determination of Nitrofurantoin in Biological Fluids

Abstract In this work, electrochemically reduced graphene oxide‐carbon nanotube (multi‐walled) nanocomposite modified glassy carbon electrode (ErGO‐CNT/GCE) has been investigated for direct electrochemical determination of nitrofurantoin (NFT), which is the prime drug used in the treatment of urinary tract infection. Surface of ErGO‐CNT/GCE has shown leafy flake‐like layers on the nanowire bed of CNTs, promising porous surface structure with enhanced surface area. ErGO‐CNT/GCE showed high peak current along with low overpotential in sensing NFT. In differential pulse voltammetry studies, the low detection limit is 20 nM. Steady state current ‐ time analyses carried out in buffer and serum samples resulted a low‐detection‐limit of 1.87 nM with the analysis time of mere 5 s. Practical application of the fabricated sensor for NFT determination in serum samples has been demonstrated.