心理学
神经科学
前额叶皮质
功能磁共振成像
工作记忆
认知心理学
执行职能
渴求
意识的神经相关物
认知
任务(项目管理)
上瘾
认知灵活性
默认模式网络
大脑活动与冥想
斯特罗普效应
神经认知
神经影像学
背外侧前额叶皮质
静息状态功能磁共振成像
作者
Weiran Zhou,Min Wang,Hui Zheng,Meng-jing Wang,Guangheng Dong
标识
DOI:10.1016/j.pnpbp.2021.110256
摘要
Abstract Background Previous studies have shown that gaming-related cues could induce gaming cravings and bring about changes in brain activities in subjects with Internet gaming disorder (IGD). However, little is known about the brain network organizations in IGD subjects during a cue-craving task and the relationship between this network organization and IGD severity. Methods Sixty-one IGD subjects and 61 matched recreational game users (RGUs) were scanned while performing a cue-craving task. We calculated and compared the participation coefficient (PC) among brain network modules between IGD subjects and RGUs. Based on the results, further group comparison analyses were performed to explain the PC changes and to explore the relationship between PCs and IGD severity. Results While performing a cue-craving task, compared with RGUs, IGD subjects showed significantly decreased PCs in the default-mode network (DMN) and the frontal-parietal network (FPN). Specifically, the number of connections between nodes in the ventromedial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex and other nodes in the DMN of IGD subjects was much larger than that in RGUs. Correlation results showed that the number of DMN intra-modular connections was positively correlated with addiction severity and craving degree. Conclusions These results provide neural evidence that can explain why cognitive control, emotion, attention and other functions are impaired in IGD subjects in the face of gaming cues, which leads to compulsive behavior toward games. These findings extend our understanding of the neural mechanism of IGD and have important implications for developing effective interventions to treat IGD subjects.
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