Nickel-Catalyzed Asymmetric Synthesis of P-Stereogenic Vinyl Phosphines

Abstract Addition reaction to alkynes is an efficient strategy for constructing valuable alkenyl compounds. However, the elusive regioselectivity has been a persistent challenge. In the context of hydrophosphination reaction which could afford valuable P-stereogenic phosphines, the control of enantioselectivity as well as regioselectivity were especially tricky. Here, we highlighted our recent work on the nickel-catalyzed regio- and enantioselective hydrophosphination of unactivated alkynes with in situ generated secondary phosphines. 1 Introduction 2 Hydrophosphination of Alkynes 3 Derivatization Reactions 4 Mechanism Research 5 Summary and Outlook