药物输送
生物相容性材料
纳米技术
生物材料
材料科学
药品
聚合
组合化学
药理学
生物医学工程
化学
计算机科学
聚合物
有机化学
工程类
生物
作者
Xu Wang,Ziyuan Song,Shiqi Wei,Guonan Ji,Xuetao Zheng,Zihuan Fu,Jianjun Cheng
出处
期刊:Biomaterials
[Elsevier]
日期:2021-08-01
卷期号:275: 120913-120913
被引量:35
标识
DOI:10.1016/j.biomaterials.2021.120913
摘要
Recent years have seen increasing interests in the use of ring-opening polymerization of α-amino acid N-carboxyanhydrides (NCAs) to prepare synthetic polypeptides, a class of biocompatible and versatile materials, for various biomedical applications. Because of their rich side-chain functionalities, diverse hydrophilicity/hydrophobicity profiles, and the capability of forming stable secondary structures, polypeptides can assemble into a variety of well-organized nano-structures that have unique advantages in drug delivery and controlled release. Herein, we review the design and use of polypeptide-based drug delivery system derived from NCA chemistry, and discuss the future perspectives of this exciting and important biomaterial area that may potentially change the landscape of next-generation therapeutics and diagnosis. Given the high significance of precise control over release for polypeptide-based systems, we specifically focus on the versatile designs of drug delivery systems capable of programmed release, through the changes in the chemical and physical properties controlled by the built-in molecular structures of polypeptides.
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