Isatin consist of 1H indole 2,3diones it is an important class of a heterocyclic compounds. Isatin analogues (or) scaffold have a wide variety of strong interest in synthesis and pharmacological activity. Isatin and its derivatives posses anti-tuberclosis or anti-mycobacterial activity. Tuberculosis is rapid growing diseases. Many Isatin scaffold are more potent then reference drug. This review aims of highlighting the diverse biological activity of Tuberclosis by Isatin scaffold