荧光团
荧光
量子产额
吸收(声学)
噻吩
光化学
呋喃
材料科学
共轭体系
近红外光谱
化学
聚合物
光学
有机化学
物理
复合材料
作者
Chunchen Liu,Mengfei Li,Haiying Ma,Zhubin Hu,Xinyuan Wang,Rui Ma,Yingying Jiang,Haitao Sun,Shoujun Zhu,Yongye Liang
出处
期刊:Research
[AAAS00]
日期:2023-01-01
卷期号:6
被引量:9
标识
DOI:10.34133/research.0039
摘要
The second near-infrared (NIR-II, 1,000 to 1,700 nm) molecular fluorophores containing donor-acceptor-donor conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red shift of absorption, enhanced absorption coefficient, and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LN surgery in tumor-bearing mice. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.
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