三氟甲基化
吡那考
化学
硼酸
芳基
催化作用
组合化学
有机化学
铜
三氟甲基
烷基
作者
Jing Liu,Yisa Xiao,Jian Hao,Qilong Shen
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-02-13
卷期号:25 (7): 1204-1208
被引量:3
标识
DOI:10.1021/acs.orglett.3c00206
摘要
A copper-catalyzed trifluoromethylation of (hetero)arylboronic acid pinacol esters with YlideFluor for the preparation of trifluoromethylated (hetero)arenes was described. The reaction conditions are mild and compatible with a broad range of functional groups. Heteroaryl boronic acid pinacol esters could also be trifluoromethylated in high yields. Application of this protocol for trifluoromethylation of drug and OLED molecules was demonstrated.
科研通智能强力驱动
Strongly Powered by AbleSci AI