Lipid Disorders and Metabolic-Associated Fatty Liver Disease

Dyslipidemia has been linked metabolic-associated fatty liver disease (MAFLD). Several genes and transcription factors involved in lipid metabolism can increase susceptibility to MAFLD. Multiple parallel ‘hits’ have been proposed for developing hepatic steatosis, NASH , and MAFLD, including insulin resistance and subsequent free fatty acid excess, de novo lipogenesis , and excessive hepatic triglyceride and cholesterol deposition in the liver. This lead to defective beta-oxidation in the mitochondria and VLDL export and increased inflammation. Given the significant cardiovascular risk, dyslipidemia associated with MAFLD should be managed by lifestyle changes and lipid-lowering agents such as statins, fenofibrate , and omega-3 fatty acids, with judicious use of insulin-sensitizing agents, and adequate control of dysglycemia .