化学
吡唑
硫代酰胺
酰胺
组合化学
催化作用
共轭体系
胺化
有机化学
过氧化氢
还原胺化
聚合物
作者
Shubham Sharma,Dharmender Singh,Sunit Kumar,. Vaishali,Rahul Jamra,Naveen Banyal,Deepika,Chandi C. Malakar,Virender Singh
摘要
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant.
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