B细胞激活因子
B细胞
免疫学
免疫系统
细胞
再繁殖
等离子体电池
生物
抗体
癌症研究
细胞生物学
干细胞
造血
遗传学
作者
Klara Asplund Högelin,Beshoy Isac,Mohsen Khademi,Faiez Al Nimer
标识
DOI:10.1016/j.clim.2023.109870
摘要
Recent studies have highlighted the important role of B cells in the pathogenesis of multiple sclerosis (MS). B cell activating factor (BAFF) and A proliferation inducing ligand (APRIL) play a major role in B cell survival and homeostasis. Here, we studied the association of BAFF and APRIL with B cell immune markers in MS and following B cell depletion and repopulation. We found that BAFF but not APRIL was significantly higher in plasma in untreated MS compared to controls. BAFF increased after rituximab treatment and decreased again during repopulation displaying an inverse correlation with B cell numbers, and more specifically switched memory B cell numbers. Cerebrospinal fluid BAFF inversely correlated with IgG index. BAFF displayed an inverse association to anti-EBV-CA antibodies. In summary, our study identified immune cells and factors that might regulate or be regulated by BAFF and APRIL levels in MS, and during B cell depletion and repopulation.
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