神经炎症
自噬
抗抑郁药
神经科学
药理学
医学
化学
心理学
炎症
内科学
海马体
细胞凋亡
生物化学
作者
Hua Gan,Qingyu Ma,Wenzhi Hao,Ni Yang,Zhe‐Sheng Chen,Lijuan Deng,Jiaxu Chen
标识
DOI:10.1016/j.phrs.2024.107112
摘要
Depression is a common disease that affects physical and mental health and imposes a considerable burden on afflicted individuals and their families worldwide. Depression is associated with a high rate of disability and suicide. It causes a severe decline in productivity and quality of life. Unfortunately, the pathophysiological mechanisms underlying depression have not been fully elucidated, and the risk of its treatment is still presented. Studies have shown that the expression of autophagic markers in the brain and peripheral inflammatory mediators are dysregulated in depression. Autophagy-related genes regulate the level of autophagy and change the inflammatory response in depression. Depression is related to several aspects of immunity. The regulation of the immune system and inflammation by autophagy may lead to the development or deterioration of mental disorders. This review highlights the role of autophagy and neuroinflammation in the pathophysiology of depression, sumaries the autophagy-targeting small moleculars, and discusses a novel therapeutic strategy based on anti-inflammatory mechanisms that target autophagy to treat the disease.
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