化疗所致周围神经病变
医学
生活质量(医疗保健)
睡眠障碍
匹兹堡睡眠质量指数
睡眠(系统调用)
物理疗法
周围神经病变
睡眠质量
精神科
失眠症
内分泌学
计算机科学
糖尿病
操作系统
护理部
作者
Fawaz Mayez Mahfouz,Tiffany Li,Masarra Joda,Michelle Harrison,Lisa G. Horvath,Peter Grimison,Tania King,Gavin Marx,David Goldstein,Susanna B. Park
标识
DOI:10.1007/s00520-023-08245-w
摘要
Abstract Purpose Sleep problems are commonly reported by cancer survivors; however, knowledge of the impact of chemotherapy-induced peripheral neurotoxicity (CIPN) on sleep quality remains limited. In this study, we explored the impact of CIPN on sleep quality, as well as identified clinical characteristics associated with poor sleep quality. Methods Participants were assessed cross-sectionally post-neurotoxic chemotherapy. CIPN severity was graded using a range of questionnaires that assessed CIPN severity and quality of life, as well as neurological grading scales. Sleep quality was assessed using a self-rated questionnaire (Pittsburgh Sleep Quality Index, PSQI). Participants with poor sleep quality were further grouped according to whether sleep impairment was due to CIPN or other factors. Results Among 77 participants who reported CIPN, 75% ( n = 58) reported poor sleep quality. Of those, 41% ( n = 24) reported CIPN as contributing to sleep impairment, while 59% ( n = 34) reported other causes. Participants with CIPN-induced sleep impairments had higher CIPN severity across all outcome measures, as well as greater neuropathic pain (all p < 0.05). Furthermore, participants with CIPN-induced sleep impairments reported worse impact of neuropathy on physical and social functioning, as well as emotional well-being (all p < 0.05). Conclusions Participants with CIPN-induced poor sleep quality reported worse scores across all CIPN severity measures. This emphasises the negative impacts of CIPN symptoms on quality of life of chemotherapy-treated patients and highlights the importance of sleep quality assessment in cancer survivors.
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