Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches

We investigate the dependency of dynamic optical coherence tomography (DOCT) signal on wavelength and resolution in two systems. One is 840-nm spectral domain OCT, and the other is 1310-nm swept-source OCT. For wavelength dependency, we made the resolution roughly the same among two systems by computationally reducing the axial resolution of 840-nm system. For resolution dependency, we compared LIV images with and without reduction of the resolution. In addition, we performed numerical simulation by modeling the intracellular scatterer dynamics by a diffusion. Experiment and simulation suggested that LIV is highly affected by the wavelength, where shorter wavelength gives higher LIV.