失调
促炎细胞因子
医学
肺癌
微生物群
肺
免疫系统
免疫学
炎症
癌症研究
肠道菌群
生物
病理
内科学
生物信息学
作者
Yangqian Li,Guanhua Rao,Guonian Zhu,Cheng Cheng,Lijuan Yuan,Chengpin Li,Jianpeng Gao,Jun Tang,Zhoufeng Wang,Weimin Liu
标识
DOI:10.1111/1759-7714.15166
摘要
Abstract Background The lung has a sophisticated microbiome, and respiratory illnesses are greatly influenced by the lung microbiota. Despite the fact that numerous studies have shown that lung cancer patients have a dysbiosis as compared to healthy people, more research is needed to explore the association between the microbiota dysbiosis and immune profile within the tumor microenvironment (TME). Methods In this study, we performed metagenomic sequencing of tumor and normal tissues from 61 non‐small cell lung cancer (NSCLC) patients and six patients with other lung diseases. In order to characterize the impact of the microbes in TME, the cytokine concentrations of 24 lung tumor and normal tissues were detected using a multiple cytokine panel. Results Our results showed that tumors had lower microbiota diversity than the paired normal tissues, and the microbiota of NSCLC was enriched in Proteobacteria , Firmicutes , and Actinobacteria . In addition, proinflammatory cytokines such as IL‐8, MIF, TNF‐ α, and so on, were significantly upregulated in tumor tissues. Conclusion We discovered a subset of bacteria linked to host inflammatory signaling pathways and, more precisely, to particular immune cells. We determined that lower airway microbiome dysbiosis may be linked to the disruption of the equilibrium of the immune system causing lung inflammation. The spread of lung cancer may be linked to specific bacteria.
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