瞬时受体电位通道
TRPM2型
氧化应激
TRPC5公司
离子通道
TRPC1型
活性氧
细胞生物学
伸展激活离子通道
化学
TRPV1型
TRPC6型
受体
生物物理学
生物
电压门控离子通道
生物化学
作者
Boying Li,Ning Li,Nana Wang,Chaoqun Li,Xiaoning Liu,Zhanshuo Cao,Chengfen Xing,Shu Wang
标识
DOI:10.1016/j.mtadv.2022.100335
摘要
Reactive oxygen species (ROS) play an important role in regulating various physiological functions by activating specific ion channels to mediate cell growth, proliferation, regeneration, and apoptosis. ROS sensitive ion channels in the transient receptor potential (TRP) channel family are closely related to oxidative stress-related diseases. Therefore, it is of great significance to regulate ROS levels and their related ion channels. This review summarizes the role of five ROS sensitive ion channels, transient receptor potential M2 (TRPM2), transient receptor potential A1 (TRPA1), transient receptor potential V1 (TRPV1), transient receptor potential M7 (TRPM7) and transient receptor potential C5 (TRPC5), in oxidative stress-related diseases. In addition, the recent research progress of using nanomaterials to regulate oxidative stress-related diseases by targeting ROS-sensitive ion channels is summarized. It is hoped that this review will provide insights for researchers to regulate ROS-sensitive ion channels to alleviate related diseases.
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