Plasma and serum BDNF differentially relate to fNIRS prefrontal cortex activity during executive function and memory tasks

Better cognitive performance and higher neural activity during episodic memory suggest that pBDNF may be involved in supporting prefrontal cortex functions for episodic memory. Different associations between pBDNF and sBDNF and both cognitive and imaging outcomes may reflect the differing bioavailability of these two BDNF pools, with implications for future mechanistic studies.