Design and Development of Carbene-Catalyzed Intramolecular Vinylogous Stetter Reaction to Access Phenanthrol Derivatives

-QM) moiety that acts as a vinylogous Stetter (1,6-conjugate) acceptor while the aldehyde functional group serves as an acyl anion equivalent, generated in situ from NHC-catalyzed umpolung. Salient features of the presented protocol include atom efficiency, operational simplicity, broad substrate scope, large-scale synthesis, and postsynthetic modifications.