Association of Dietary Index for Gut Microbiota With Hyperuricemia in Adults: A Cross‐Sectional Study of NHANES 2007–2018

ABSTRACT Objective To detect the potential association between the dietary index for gut microbiota (DI‐GM) and hyperuricemia. Method Utilizing cross‐sectional analysis of National Health and Nutrition Examination Survey (NHANES) data, a multivariable logistic regression model was employed to reveal the impact of DI‐GM on uric acid levels. The results indicate that participants with hyperuricemia had significantly lower DI‐GM levels compared to those without hyperuricemia (OR = 0.93, 95% CI: 0.91–0.95, p < 0.001). Furthermore, even after adjusting for covariates, the association between DI‐GM and hyperuricemia remained significant (OR = 0.97, 95% CI: 0.95–0.99, p = 0.012), suggesting a risk factor association between high DI‐GM and low uric acid levels. The study also revealed a gradual decrease in the risk of hyperuricemia with increasing DI‐GM, indicating the potential of DI‐GM as a prognostic assessment marker ( p for overall < 0.001). Additionally, a weak negative correlation between DI‐GM and chronic kidney disease (CKD) was observed among patients with hyperuricemia (Adjusted OR = 0.90, 95% CI: 0.82–0.99, p = 0.027). Conclusion These findings support the utility of DI‐GM as a potential biomarker with important implications for the prevention and treatment of hyperuricemia. This discovery provides a crucial basis for the development of future dietary interventions and strategies related to gut microbiota, warranting further in‐depth research to validate its applicability and effectiveness in diverse populations.