Characterization of Mass Spectrometry Fragmentation Patterns Under Electron‐Activated Dissociation (EAD) for Rapid Structure Identification of Nitazene Analogs

The fragmentation pathways of the main fragment ions were elucidated based on the EAD-MS² spectra. Based on the summarized mass spectrometry characteristics of nitazene analogs, a flowchart was developed to guide the structure prediction of novel nitazene derivatives encountered in forensic casework. EAD was recognized as a perfect technique for accurate structure prediction and identification of new emerging nitazene analogs.