化学
废止
芳基
吖啶酮
重氮甲烷
芳基
组合化学
高价分子
功能群
有机化学
催化作用
试剂
聚合物
烷基
作者
Min Luo,Ning Dong,Mengyao Zhu,Yongfeng Wang,Cheng Xu,Guodong Yin
标识
DOI:10.1021/acs.joc.3c00250
摘要
A tert-butyl hydroperoxide-promoted oxidative annulation reaction of isatins with 2-(trimethylsilyl)aryl triflates for the convenient synthesis of acridone derivatives has been established. Mechanistic investigation suggested that the reaction may proceed via consecutive Baeyer–Villiger-type rearrangement followed by an intermolecular cyclization. This synthetic approach offers several advantages, including broad substrate scope, good functional group tolerance, and simplicity of operation. Additionally, successful late-stage modification of the obtained compounds was achieved, expanding the application potential of this methodology in organic synthesis.
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