医学
帕金森病
脑深部刺激
运动障碍
物理医学与康复
疾病
阿扑吗啡
重症监护医学
运动症状
左旋多巴
吞咽困难
神经科学
多巴胺能
心理学
多巴胺
外科
病理
作者
Ryan Wang,Ludy C. Shih
标识
DOI:10.1097/wco.0000000000001166
摘要
Purpose of Review The purpose is to review the results and impact of recent studies for current and future treatment of both motor and non-motor symptoms in Parkinson's disease (PD). Recent Findings New formulations of levodopa further optimize motor fluctuations, allowing for more on-time and less dyskinesia. On demand apomorphine continues to showcase itself as an effective and tolerable tool for treating motor off-periods. Though there are no clear treatment guidelines for PD-related constipation and sleep related disorders, several new agents for these non-motor symptoms show promising preliminary data. Expiratory muscle strength training may represent a useful and cost-effective strategy to alleviate oropharyngeal dysphagia associated with PD. There is evidence to suggest that the use of shorter pulse width and directional deep brain stimulation leads can results in a greater therapeutic window. Summary Though no interventions currently exist to significantly modify the disease progression of PD, new studies continue to give insight into optimal symptomatic management. Clinicians should be familiar with expanding the repertoire of tools available to treat the diverse range of symptoms and challenges associated with PD.
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