痴呆
血压
医学
危险系数
内科学
认知功能衰退
心脏病学
认知
冲刺
比例危险模型
物理疗法
置信区间
疾病
精神科
作者
Sitong Li,Chao Jiang,Yufeng Wang,Yiwei Lai,Manlin Zhao,Qifan Li,Yu Bai,Wenli Dai,Qi Guo,Liu He,Xueyuan Guo,Wei Wang,Songnan Li,Nian Liu,Chen‐Xi Jiang,Ri‐Bo Tang,Caihua Sang,Deyong Long,Xin Du,Jianzeng Dong,Craig S. Anderson,Changsheng Ma
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2023-08-01
卷期号:80 (8): 1628-1636
被引量:3
标识
DOI:10.1161/hypertensionaha.122.20711
摘要
The prognostic value of systolic blood pressure (SBP) time in target range (TTR) on cognitive outcomes among adults with hypertension remains unclear.We performed secondary analysis of SPRINT MIND (Systolic Blood Pressure Intervention Trial Memory and Cognition in Decreased Hypertension), which compared intensive (<120 mm Hg) versus standard (<140 mm Hg) SBP intervention in hypertensive individuals. TTR was calculated from baseline to month 3 using 110 to 130 mm Hg and 120 to 140 mm Hg as target range for the intensive and standard groups, respectively. Cognitive outcomes included probable dementia, mild cognitive impairment, and the composite of probable dementia or mild cognitive impairment. Cox regression models were used to evaluate the relationship between SBP-TTR and cognitive outcomes.A total of 8298 patients were included. Participants with higher TTR were younger and less likely to be women or to have a history of cardiovascular disease. After adjustment of baseline demographics, medical history, and mean SBP, a 1-SD (31.5%) increase in TTR was independently associated with a 14% lower risk of probable dementia (hazard ratio, 0.86 [95% CI, 0.76-0.98]; P=0.023). Sensitivity analysis showed consistent results when combining target range as 110 to 140 mm Hg. However, there was no significant association between SBP-TTR and mild cognitive impairment.In this post hoc analysis of SPRINT MIND, SBP-TTR was an independent predictor of probable dementia beyond mean SBP. Maintaining SBP within 110 to 140 mm Hg over time may be beneficial for dementia prevention.URL: https://www.gov; Unique identifier: NCT01206062.
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