A Subjective Evaluation of the Effects of a Probiotic Formulation on Skin Quality in Young Adult Females: Open-Label Proof-of-Concept Study

This pilot, proof-of-concept, study was designed to assess the effect of a blend of Lactobacillus helveticus Rosell®-52 and Bifidobacterium longum Rosell®-175 on parameters of skin quality. Capsules containing L. helveticus Rosell®-52 and B. longum Rosell®-175 were given to 35 healthy women (3 billion CFU/d for 56 days), and assessments of skin quality were performed at baseline, as well as on days 28 and 56. Importantly, the formulation significantly reduced the appearance of fine lines and improved skin firmness, elasticity, and hydration. In addition, study participants experienced improvements in sleep quality and felt less stressed (PSS-10 subjective stress questionnaire). Taken together, these results provide the rationale to conduct a larger, placebo-controlled trial and to assess the effects of the oral probiotic intake in healthy women with more visible signs of skin aging.