Cancer Risks Associated With Germline Mutations in <emph type="ital">MLH1</emph>, <emph type="ital">MSH2</emph>, and <emph type="ital">MSH6</emph> Genes in Lynch Syndrome

MSH6 mutations are associated with markedly lower cancer risks than MLH1 or MSH2 mutations. Lifetime ovarian and endometrial cancer risks associated with MLH1 or MSH2 mutations were high but do not increase appreciably until after the age of 40 years.