生物
胚胎干细胞
诱导多能干细胞
干细胞
细胞生物学
胚胎
细胞分化
发育生物学
定向微分
进化生物学
神经科学
遗传学
基因
作者
Janet Rossant,Patrick Tam
出处
期刊:Cell Stem Cell
[Elsevier]
日期:2017-01-01
卷期号:20 (1): 18-28
被引量:214
标识
DOI:10.1016/j.stem.2016.12.004
摘要
Pathways underlying mouse embryonic development have always informed efforts to derive, maintain, and drive differentiation of human pluripotent stem cells. However, direct application of mouse embryology to the human system has not always been successful because of fundamental developmental differences between species. The naive pluripotent state of mouse embryonic stem cells (ESCs), in particular, has been difficult to capture in human ESCs, and appears to be transitory in the human embryo itself. Further studies of human and non-human primate embryo development are needed to untangle the complexities of pluripotency networks across mammalian species.
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