光动力疗法
光热治疗
活性氧
癌症治疗
放射治疗
癌症治疗
纳米技术
化学
癌症
材料科学
癌症研究
医学
内科学
生物化学
有机化学
作者
Minhuan Lan,Shaojing Zhao,Weimin Liu,Chun‐Sing Lee,Wenjun Zhang,Pengfei Wang
标识
DOI:10.1002/adhm.201900132
摘要
Abstract As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O 2 ). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials. The strategies to improve ROS generation through optimizing photoinduced electron transfer and energy transfer processes of PSs are highlighted. Moreover, the approaches that combine PDT with other therapeutics (e.g., chemotherapy, photothermal therapy, and radiotherapy) and the targeted delivery in cancer cells or tumor tissue are introduced. The main challenges for the clinical application of PSs are also discussed.
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