模式识别受体
先天免疫系统
获得性免疫系统
免疫系统
生物
程序性细胞死亡
多细胞生物
受体
病原相关分子模式
炎症
细胞生物学
免疫
有机体
免疫原性细胞死亡
免疫学
细胞
免疫疗法
细胞凋亡
遗传学
作者
Gustavo P. Amarante-Mendes,Sandy Adjemian,Laura Migliari Branco,Larissa C Zanetti,Ricardo Weinlich,Karina Ramalho Bortoluci
标识
DOI:10.3389/fimmu.2018.02379
摘要
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns-PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns-DAMPs). They emerged phylogenetically prior to the appearance of the adaptive immunity and, therefore, are considered part of the innate immune system. Signals derived from the engagement of PRRs on the immune cells activate microbicidal and pro-inflammatory responses required to eliminate or, at least, to contain infectious agents. Molecularly controlled forms of cell death are also part of a very ancestral mechanism involved in key aspects of the physiology of multicellular organism, including the elimination of unwanted, damaged or infected cells. Interestingly, each form of cell death has its particular effect on inflammation and on the development of innate and adaptive immune responses. In this review article, we discuss some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs.
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