A preclinical model of post-surgery secondary bone healing for subtrochanteric femoral fracture based on fuzzy interpretations

Mechanobiology plays an essential role in secondary bone fracture healing. While the introduction of newer type of plates, e.g. locking plate (LP), is becoming increasingly popular for complex femoral fractures, the conventional technique involving dynamic compression plate (DCP) remains the standard choice. The difference between the two techniques lies primarily in their screw fixation mechanisms. The present study applied 3D dynamic fracture healing scheme modelled on a subtrochanteric femur fracture, regulated by both finite element (FE) analysis and Fuzzy logic control in order to understand the spatio-temporal healing phenomena for both LP and DCP. The study further examined the influence of the two screw fixation mechanisms in determining the comparative progression of fracture healing. The problem was solved iteratively in several healing steps running in loop and accordingly, the local tissue concentrations and material properties were updated. The predicted results accorded well with various previous experimental observations. The study found an initial delay in healing associated with DCP. However, as the healing progressed, there was no significant difference in overall callus modulus. The presented preclinical model may further help predict bone healing for different implantation techniques, and thus can serve as a non-invasive tool for evaluating relative merits of extramedullary plating techniques.