生发泡
微量注射
卵母细胞
爪蟾
化学
细胞生物学
促成熟因子
生物
胚胎
生物化学
基因
细胞周期
细胞周期蛋白依赖激酶1
作者
Noriyuki Sagata,Ira Daar,M Oskarsson,Showalter Sd,GF Vande Woude
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1989-08-11
卷期号:245 (4918): 643-646
被引量:329
标识
DOI:10.1126/science.2474853
摘要
The endogenous c- mos product, pp39 mos , is required for progesterone-induced meiotic maturation in Xenopus oocytes. Treatment of oocytes with progesterone induced a rapid increase in pp39 mos that preceded both the activation of maturation promoting factor (MPF) and germinal vesicle breakdown (GVBD). Microinjection of synthetic mos RNA into oocytes activated MPF and induced GVBD in the absence of progesterone. Thus, the mos proto-oncogene product may qualify as a candidate "initiator" protein of MPF and is at least one of the "triggers" for G 2 to M transition.
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