Effect of Multi-nano-titania Film on Proliferation and Differentiation of Mouse Fibroblast Cell on Titanium

This investigation studies how nano-( , , and ) phases affect the formation of multi-nano-titania film by anodization and cathodic pretreatment. Nano-titanium hydrides and substoichiometric nano-titanium hydrides were formed during cathodization. A multi-nanoporous titania film was formed on the titanium during anodization. The nanohydrides are directly transformed to multi-nanoporous titania film by dissolution following anodization. Anodization with cathodic pretreatment not only yields a titanium surface with a multi-nanostructure, but also transforms the titanium surface into a nanostructured titania surface. Formation of nanohydrides by cathodization and oxidation by anodization are believed to promote biocompatibility and improve bone-to-interface contact, accelerating initial osseointegration and re-osseointegration.