药代动力学
氧化应激
化学
氟伏沙明
内分泌学
内科学
分布(数学)
药理学
医学
生物化学
受体
血清素
氟西汀
数学
数学分析
作者
Shinji Kobuchi,Keizo Fukushima,Yoshiaki Ito,Nobuyuki Sugioka,Kanji Takada
标识
DOI:10.3109/10715762.2012.683430
摘要
The effects of oxidative stress (OS) on the pharmacokinetics of fluvoxamine (FLV), particularly on FLV distribution in the plasma, were studied in ferric-nitrilotriacetate-induced OS rat models (OS rats). The study protocol involved a continuous FLV infusion (25.0 μg/kg/min). The resulting mean plasma FLV concentration measured in steady state OS rats was 0.13 ± 0.01 μg/mL, which was significantly lower than plasma concentrations measured in control rats (0.19 ± 0.01 μg/mL). Moreover, the mean FLV concentration in the OS rat brain (0.51 ± 0.08 μg/g) was determined to be approximately half the concentration in control rat brains (0.95 ± 0.11 μg/g). The FLV concentrations in both the unbound fraction of plasma and erythrocytes of OS rats were significantly greater than that of control rats. These results suggest the potential attenuation of FLV's pharmacological effects in patients under OS.
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