免疫学
医学
发病机制
细胞因子
白细胞介素
外周血单个核细胞
红斑狼疮
血清学
白细胞介素6
抗体
生物
体外
生物化学
作者
Mariana Linker‐Israeli,Antony C. Bakke,Rodanthi C. Kitridou,Sandra J. Gendler,Steven Gillis,David A. Horwitz
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1983-06-01
卷期号:130 (6): 2651-2655
被引量:371
标识
DOI:10.4049/jimmunol.130.6.2651
摘要
The objective of this study was to define some causes of the immunologic impairment characteristic of systemic lupus erythematosus. Blood mononuclear cells from 19 patients were stimulated to produce interleukin 1 and interleukin 2 and compared with controls. A severe defect in both IL 1 and IL 2 activity was observed. The low cytokine levels did not correlate with clinical or serologic activity of disease. These defects could not be explained by concurrent corticosteroid therapy. There was no correlation between a lower number of OKT4+ cells observed in these patients and the levels of IL 2 production, nor did removal of monocytes bring IL 2 to normal. Impaired IL 2 production could not be restored to normal by IL 1. The observed deficiency in these regulatory cytokines may therefore be a primary defect that is important in the pathogenesis of this disorder.
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