基因传递
免疫原性
遗传增强
质粒
聚合物
阳离子聚合
可生物降解聚合物
病毒载体
体内
DNA
化学
基因
纳米技术
生物
生物技术
生物化学
材料科学
重组DNA
遗传学
抗原
高分子化学
有机化学
作者
Jordy Luten,Cornelus F. van Nostrum,Stefaan C. De Smedt,Wim E. Hennink
标识
DOI:10.1016/j.jconrel.2007.10.028
摘要
Gene therapy holds a great promise for the treatment of acquired and inherited diseases with a genetic origin that are currently incurable. Non-viral gene delivery systems are gaining recognition as an alternative to viral gene vectors for their potential in avoiding immunogenicity and toxicity problems inherently associated with the use of viral systems. Many cationic polymers have been studied both in vitro and in vivo for gene delivery purposes. However, in recent years there has been a focus on biodegradable carrier systems. The potential advantage of biodegradable carriers as compared to their non-degradable counterparts is their reduced toxicity and the avoidance of accumulation of the polymer in the cells after repeated administration. Also, the degradation of the polymer can be used as a tool to release the plasmid DNA into the cytosol. In this article the recent results obtained with two classes of degradable gene delivery systems, namely those based on water-soluble cationic polymers and on micro- and nanoparticles will be summarized and discussed.
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